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KMID : 0043320080310080999
Archives of Pharmacal Research
2008 Volume.31 No. 8 p.999 ~ p.1003
New Butyrylcholinesterase Inhibitory Steroid and Peroxy Acid from Leucas urticifolia
Fatima Itrat

Ahmad Ijaz
Anis Itrat
Malik Abdul
Afza Nighat
Iqbal Lubna
Latif Mehreen
Abstract
A new steroid leucisterol (1) and a new peroxy acid urticic acid (2) along with methoxybenzyl benzoate (3), 4-hydroxy benzoic acid (4), -sitosterol (5), and ursolic acid (6), have been isolated from the chloroform soluble fraction of the whole plant of Leucas urticifolia. Their structures were elucidated on the basis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Leucisterol showed potent inhibitory activity against butyrylcholinesterase enzyme.
KEYWORD
Leucas urticifloia, Labiatae, Leucisterol, Urticic acid, Butyrylcholinesterase inhibition
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